The 27-year-old did not feature against the Saints in the FA Cup tie at the weekend due to an unspecified fitness problem, and he only lasted 78 minutes in the league victory yesterday evening.
Kieran Tierney missed the doubleheader versus Southampton with a leg injury and Arteta has said that the player is still struggling with the issue. He is a major doubt for the United clash.
Emile Smith Rowe has a muscular problem, and while he was fit to play the first 70 minutes last night, it appears that he is still not 100%. He could well play at the weekend if he manages to pass a fitness test.
Dani Ceballos and Pablo Mari (both calf) are expected to be back in training this week. However, it is not known whether they will be ready to play against United on Saturday.