Bizarrely William Gallas also wore the shirt for four seasons at the Emirates despite being a centre half.
Ozil had taken it for the past two and a half seasons but after he was unveiled at Fenerbahce on Wednesday, the spot is vacant once more.
So who should take it? Here footballaudit.com takes a look at the main candidates.
Emile Smith Rowe
There was some thinking that Emile Smith Rowe could take the number 10 shirt straight away after Ozil’s departure
The 20-year-old has been sensational since establishing himself in Mikel Arteta’s first team after Boxing Day and will surely be a fixture for years to come.
Premier League rules dictate that clubs are allowed to change squad numbers midway through the season although football.london understands that Arsenal have not applied to.
Being handed the jersey would represent an immense show of faith in the youngster who deserves it after his recent performances
Before Mesut Ozil’s departure had even been announced Alexandre Lacazette had eyes on the German’s former squad number.
He joked on social media about a battle with Pierre-Emerick Aubameyang in order to claim the 10 shirt.
The Frenchman wore it during his time at Lyon, and Aubameyang seemed to pave the way for him to take the number if he wants it.
Lacazette is currently Arsenal’s number 9, but with his future up in the air it’s not clear whether he will be able to go up one to 10.
Emi Buendia was heavily linked to Arsenal this transfer window before Mikel Arteta and Edu settled on signing Martin Odegaard.
Depending on how the Norwegian gets on at the Emirates that interested could well be reignited come the summer.
If the Gunners did make a bid for the Argentinian then offering him the number of the creator-in-chief would be a clear sign of their intentions for him.
This is all dependent on if Norwich are able to get promotion back to the Premier League though. If they’re successful Buendia may well be out of Arsenal’s price range, but if they end up staying in the Championship it could be a very different story
The dream that so many Arsenal fans want to see would be to have Jack Grealish wearing the number 10 shirt in north London.
The England international has admitted that the Emirates is his favourite surface to play on and would surely be a perfect fit.
However, once again pricing may prove to be an issue for Arsenal. Grealish signed a long-term contract extension last summer and Aston Villa are unlikely to let him go on the cheap.